THE GENE WAR ...THE MASSACRE OF THE KILLING TOMATOES 1988 CORNELL UNIVERSITY A NATURAL INEXPENSIVE TREATMENT WICH WILL KEEP RIPE AND TASTY? TOMATOES LONGER IN THE SHELFS FROM THE BIOLOGICAL AND BIOCHEMICAL CLUES OF THE VARIETY ALCOBAÇA ...THAT THE PORTUGUESE TOOK TO BRAZIL 10 TO 14 DAYS OF TOMATOES BEFORE THIS THE NORMAL FRESH TOMATO ARE TROW AWAY AFTER 4 OR 5 DAYS - CONCENTRATION OF 1,4 BUTANEDIAMINE ARE TWICE IN THE ALCOBAÇA VARIETY INFUSING POLYAMINES IN THE RUTGER VARIETY BY VACUUM INFILTRATION THROUGH IN OR THROUGH OUT THE STEM SCAR 28 SEPTEMBER 1988 A NEW AGE FOR TOMATOES GENES FOR LONG SHELF LIFE

Ehrlich’s “gorged cells”
Mast cells, whose differentiation pathways and heterogeneity
are still poorly understood, originate from precursors of
the haematopoietic lineage and circulate in blood and the
lymphatic system before homing to tissues and acquiring
their final effector characteristics. The expansion, homing
and maturation of mast cell precursors are influenced by
several cytokines including interleukin 4 (IL-4), IL-9 and
nerve growth factor (NGF)2, but stem-cell factor (SCF)
binding to its receptor c-Kit seems to be the main drive for
their differentiation and survival: SCF-deficient (Sl/Sld) and
c-Kit-deficient (W/Wv) mice are largely, albeit not
completely, devoid of mast cells (for review, see refs 2, 3).
Mast cell produce an impressively broad array of mediators
and cell–cell signalling molecules, and it may be this
very breadth that confers on the mast cell its individuality in
the immune system. Many of these mediators, including
histamine, numerous specific proteases (members of the
tryptase and chymase families) and tumour-necrosis factora
(TNF-a), are released by triggered exocytosis from rich
intracellular stores. The fast release of TNF-a is noteworthy
because of the pleitropic pro-inflammatory effects of this
cytokine, and because mast cell granules are a plentiful
source of rapidly mobilizable TNF-a (ref. 4), whose usually
slower induction is the result of activated synthesis in other
cell systems.
On activation, mast cells also rapidly synthesize bioactive
metabolites of arachidonic acid, prostaglandins and
leukotrienes. A specific program of gene expression is also
activated, leading to de novo synthesis of several cytokines
(IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, IL-14 and NGF),
chemokines (macrophage inflammatory protein